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Mitochondrial Transplantation in PD Improving mitochondrial function by supplementing exogenous mitochondria is a promising strategy in PD (Shanmughapriya et al., 2020)

401 Ferroptosis in thalassemia Thalassemia is a common monogenic inherited disorder primarily caused by a reduction in globin synthesis due to deletion or point mutations of globin gene clusters

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What Depletes BH4 Oxidative Stress Inflammation, toxins, poor diet oxidize BH4 to BH2 MTHFR Mutations Impaired folate impaired BH4 recycling Aluminum Directly inhibits BH4 synthesis Chronic Infections Immune activation consumes BH4 Supporting BH4 Production Methylfolate (5-MTHF) Active folate helps regenerate BH4

Studies that look into DSIPs effects on opioid pathways show it involves complicated processes, not just connecting to receptors

M.KleemannR.et al (2023)