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In addition, there was an observed increase in the levels of protein expression for markers of microglia (CD11b and Iba-1), as well as an upregulation of factors associated with pyroptosis, namely NLRP3, caspase-1, and ASC following the expression of circHIPK three

Ma FX, Zhou B, Chen Z, Ren Q, Lu SH, Sawamura T, et al

Changes in the properties of superoxide dismutase

Journal of Neuroinflammation 7: 72

(27) demonstrated that bioactive cytokines secreted by bones can enter the peripheral circulation and cross the BBB, thus modulating the function and metabolism of the CNS, playing a crucial central regulatory role