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doi: 10.1146/annurev-micro-032521-015858 61 ChowdharyA.MeisJ

Pharmacodynamics: TB-500 is a synthetic fragment of Thymosin Beta-4 that facilitates tissue regeneration by regulating actin polymerization, enhancing cellular migration, and promoting angiogenesis

New Episode News and Public Affairs Top journalists deliver compelling original analysis of the hour's headlines

Leitsch, D

Upregulation of iron transport proteins such as transferrin (Tf), transferrin receptor (TfR), and divalent metal transporter 1 (DMT1) enhances cellular iron uptake, while loss or dysfunction of ferroportin 1 (FPN1) hampers iron efflux, leading to intracellular iron overload and oxidative damage