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The mitochondrial thioredoxin system may be essential for mammalian development because disruption of Trx2 gene in the mouse resulted in massive apoptosis during early embryogenesis and embryonic lethality [166]

If they do, then you can hold them at that dose let symptoms settle, and then you can begin to withdraw the B12 liposomal down to x2 a week, and assess if the clinical changes are maintained