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[112] investigated whether there was a correlation between C677T polymorphism, birth weight, and the risk of developing CVD in 113 morbidly obese French adolescents (BMI = 39.1 6.4 kg/m 2 ) at the age of 14.4 1.5 years

Parkin then ubiquitinates outer mitochondrial membrane proteins, recruiting autophagy receptors like OPTN and NDP52, ultimately leading to the engulfment and degradation of damaged mitochondria by autophagosomes (Zhang C

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Nano-curcumin prevents cardiac injury, oxidative stress and inflammation, and modulates TLR4/NF-B and MAPK signaling in copper sulfate-intoxicated rats

This results in joint pain, deformity, and disability (Yoo et al., 2009)

The 2-oxoacid dehydrogenase complexes in mitochondria can produce superoxide/hydrogen peroxide at much higher rates than complex I