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The main obstacle of such treatments is the necessity of spraying for several consecutive days, which could be overcome by targeted delivery systems

101 Combined with the persistence of functional cure and the great improvement of clinical outcome of liver disease, the continuous seroclearance of high-sensitivity or ultra-sensitive quantitative HBsAg likely reflects a complete cure of CHB, which is similar to the treatment of chronic hepatitis C virus (HCV) infection

For these reasons, the SRTM approach used in the Asai et al

Hu C, Sun J, Zhang Y, Chen J, Lei Y, Sun X, et al

Anson et al., 2021)

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