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An emerging strategy to address ROS accumulation toxicity involves developing or characterizing small molecules that specifically scavenge ROS at particular intracellular sites

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Mutation A1298C of methylenetetrahydrofolate reductase: risk for early coronary disease not associated with hyperhomocysteinemia

The Ap-YTDBs can non-covalently cross-interact with each other via hybridization reaction because they are designed to have palindromic sticky-ends at every vertex, forming the compact protective coating with unconventional ligands, aptamers, orienting outward from siRNA/Ap-CS surface (step III)

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Safety assessments included treatment-emergent adverse events (AEs), vital signs (BP and HR), bodyweight, physical examinations and laboratory parameters