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Nanoparticle- and liposome-carried drugs: new strategies for active targeting and drug delivery across blood-brain barrier

[43a] Taken together, the molecular consequences of MBR and WTL SOD1 mutations appear to merge into a single unifying theme underlying SOD1 protein misfolding: mutations not only disrupt SOD1 maturation to promote the accumulation of disordered immature SOD1 conformers, but may substantially accentuate structural instability within already disordered microenvironments in apoSOD1

doi: 10.1016/j.jinorgbio.2011.11.020 2

It was found that subjects receiving PUVA and PL had a higher proportion of patients with repigmentation of 50% or more [137]

We highlight its role in mitigating oxidative stress, regulating mitochondrial function, modulating neuroinflammatory signaling, and promoting neurogenesis and synaptic remodeling