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It is made up of three amino acids: cysteine, glycine, and glutamic acid

Consistent with the finding that there is no apparent increase in enzymatic activity, the transcript levels of genes encoding -glutamylcysteine synthetases did not change significantly either

doi: 10.1245/s10434-018-6662-8 133 MontfortAPearceOManiatiEVincentBGBixbyLBohmSet al

Some of these are small molecules that specifically inhibit the different protein complexes of the ETC, while uncoupler proteins or molecules create holes in the membrane and destroy the H+ gradient resulting from electron flow through complex I, III, and IV of the ETC

A great deal of effort has been focused on releasing the feedback inhibition caused by GSH