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Metastasis, the spread of cancer cells from the primary tumor to distant sites, is a hallmark of cancer and a major cause of cancer-related mortality [117]

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The topical use of AKE improved all clinical dry eye symptoms in a dose-dependent manner by promoting the generation of tear fluid and mucin, while demonstrating a favorable safety profile for topical usage [91]

Similar to the mechanism of action of Rb1, Rd can significantly improve the systolic dysfunction, fibrosis, myocardial hypertrophy, inflammation and oxidative stress caused by pressure load in mice

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Given that suppressing mTOR expression inhibits PNI in pancreatic cancer, we speculated whether mTOR is required for the HGF/c-Met signaling pathway to exert its promoting effects on PNI in pancreatic cancer