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Meanwhile, the activation of MAPK may further upregulate the expression of NOX, forming a vicious cycle and aggravating the development of nephropathy

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Eun-Jeong Kwon and Moon-Moo Kim found that agmatine could increase melanin synthesis and TYR activity by regulating the MITF transcription factor via the BMP-6/p38 signalling pathway in B16F1 cells [117]