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Bates JT, Weber RJ, Abrams J et al (2015) Reactive oxygen species generation linked to sources of atmospheric particulate matter and cardiorespiratory effects

In zebrafish, Grx2 is an essential protein for successful embryogenesis, regulating neuronal survival and axon growth [92] as well as angiogenesis through S-glutathionylation of the histone-deacetylase sirtuin1 [93,94]

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Guidelines by condition type: Acute recovery (corneal injury, optic neuritis, post-surgical), 4-8 weeks then discontinue once healed

Thus phosphorylation of TDP-43, in addition to cleavage, may be additional mechanisms to regulate TDP-43 proteostasis in the event of SUMOylation-pathway failure