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The choice of suitable linker chemistry is often based on intuition, but the significant pH difference between endosomes and the extracellular space (pH 2) makes it easier to achieve selective release

If this system is disrupted, such as by selective small-molecule inhibitors, like iFSP1, or by gene deletion, the loss of FSP1 function promotes ferroptosis

Topiramate, another anti-seizure drug, improves brain homocarnosine and GABA levels, contributing to its potent anti-epileptic action in patients with complex partial seizures 127

Br J Cancer 81 : 727732 Gasparini G et al

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Sato I, Morita I, Kaji K, Ikeda M, Nagao M, Murota S