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Huntington's disease Huntington's disease is an inherited neurodegenerative disorder characterized by selective degeneration of nerve cells known as striatal spiny neurons

Vitamin Supplementation as Possible Prophylactic Treatment against Migraine with Aura and Menstrual Migraine Munvar Miya Shaik and Siew Hua Gan

(XLSX 12 kb) Supplemental Table 2 (download XLSX Nutritional assessment

The findings here showing that OTUB1-C91S increases SLC7A11 and GSH similar to OTUB1-WT, while OTUB1-D88A disrupts GSH, and that OTUB1-SSG promotes binding of the E2-conjugating enzyme, UBCH5A, collectively confirm a noncanonical mechanism of action of OTUB1 in the stabilization of SLC7A11

LC-MS/MS acquisitions For the discovery cohort, untargeted analysis samples were analyzed by nanoLC/MSMS using a Dionex UltiMate 3000 nanoRSLC liquid chromatography system (Thermo Fisher Scientific) interfaced to an Orbitrap Fusion Tribrid mass spectrometer (Thermo Fisher Scientific, San Jose, CA,USA) equipped with a nanoelectrospray ion source

For the science on individual compounds, see our evidence-based peptide guide