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The LDH release was determined using a LDH cytotoxicity detection kit (Roche, Mannheim, Germany) according to the manufacturers protocol

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An important limitation of the present study is the substantial imbalance in case numbers across ancestry groups: European ancestry participants (2,302 cases) comprise the largest group, followed by African ancestry (1,339 cases), with considerably fewer cases among Admixed American/Latino participants (465 cases)