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The majority of diagnostics are biomarker based, with one individual biomarker test, She Sense, developed by OnaWave Medical, and ten based on multiple biomarker detection

Meanwhile, IL-1 upregulates IFI16 expression via m6A epigenetic modification, inducing inflammatory apoptosis of PAECs, revealing the epigenetic regulation of metabolic pathways by inflammatory factors (Rao et al., 2025)