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Get emergency help right away if you have any symptoms of a heart attack, blood clot, or stroke while using OPZELURA, including: discomfort in the center of your chest that lasts for more than a few minutes, or that goes away and comes back severe tightness, pain, pressure, or heaviness in your chest, throat, neck, or jaw pain or discomfort in your arms, back, neck, jaw, or stomach shortness of breath with or without chest discomfort breaking out in a cold sweat nausea or vomiting feeling lightheaded weakness in one part or on one side of your body slurred speech swelling, pain, or tenderness in one or both legs Tell your healthcare provider right away if you develop or have worsening of any symptoms of low blood cell counts, such as: unusual bleeding, bruising, tiredness, shortness of breath, or fever

Pavlides S, et al

doi: 10.1016/j.smim.2021.101523 67 JaguinMHoulbertNFardelOLecureurV

In TDP-43 K408R/K408R neurons however we observed the initiation of stress granule formation in the first 30 min of stress that followed by inappropriate reactivation and recovery following subsequent rounds of stress

Note: Minimize exposure to moisture and repeated freezethaw cycles

doi: 10.1186/s12263-021-00703-6 114 XuW.LiangS.HuangY.ZhaoS.ZhangY.LiY