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It has been suggested that activation of the SSP is important not only for serine production, but can also contribute to the generation of -ketoglutarate (through the PSAT1 reaction) 14 or the redox balance in the cell (as PHGDH consumes NAD + ) 40

Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing

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Other constituents of tobacco smoke, such as carbon monoxide, along with oxidative stress, appear to play additional roles

80, e50890.10.3791/50890 161 Van SlykeP.AlamiJ.MartinD.KuliszewskiM.Leong-PoiH.SeftonM

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