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A: While generally safe, broader medical agencies like HFEA highlight inconclusive evidence and some concerns, so it should be used with clinician oversight

In cultured cardiomyocytes, DOX concentrates in mitochondria, increasing mitochondrial iron deposition and ROS levels, and dexrazoxane has demonstrated efficacy in reversing DOX-induced cardiomyopathy by lowering mitochondrial iron levels

Maugeri et al

Pardieu, B

Comparison between single and combined post-treatment with S-Methyl-N,N-diethylthiolcarbamate sulfoxide and taurine following transient focal cerebral ischemia in rat brain