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On a more encouraging note, U.S

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Stacking three or more compounds simultaneously without staggered introduction creates confounded data where attribution of specific effects becomes methodologically impossible

NPJ Parkinsons Dis 7:21 Fernandez-Pajarin G, Sesar A, Ares B, Castro A (2016) Evaluating the efficacy of nocturnal continuous subcutaneous apomorphine infusion in sleep disorders in advanced Parkinsons disease: the APO-NIGHT STudy