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Subsequent O- methylation of phenolic acids/esters Theoretically, caffeate can be either converted to caffeoyl CoA by 4CL, with subsequent O -methylation by caffeoyl CoA 3- O -methyltransferase (CCoAOMT), or first be methylated by caffeic acid 3- O -methyltransferase (COMT), with subsequent conversion to feruloyl CoA by 4CL (Fig

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10 Simone DA, Ngeow JYF, Putterman GJ, LaMotte RH