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The failure of broader or less specific agents, therefore, reinforces the central theme that therapeutic success in MIRI demands a highly targeted approach that addresses the specific downstream consequences of the initial oxidative insult

Where I 2 values greater than 40% or a chi-square statistic with a p-value less than 0.1 indicated significant statistical heterogeneity, a random-effects model was employed ( Results Description of included studies Initial search resulted in 658 records

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J., Bakke, J

Expert Opin Drug Metab Toxicol 5:10231038 Nicholson JK, Lindon JC, Holmes E (1999) Metabonomics: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data

doi: 10.3389/fpsyg.2014.01504