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Faisal Z, Mazhar A, Batool SA, Akram N, Hassan M, Khan MU, Afzaal M, Hassan UU, Shah YA, Desta DT

they lose their ability to produce erythropoietin as they transdifferentiate into myofibroblasts following kidney injury In anaemia associated with renal disease, erythropoiesis is suppressed due to the combined and interrelated effects of erythropoietin deficiency, inflammatory cytokines and iron deficiency The pharmacologic activation of hypoxia responses with HIF stabilizers provides a physiologic and comprehensive approach to the treatment of renal anaemia and warrants large, long-term clinical safety and efficacy trials Abstract Improved understanding of the oxygen-dependent regulation of erythropoiesis has provided new insights into the pathogenesis of anaemia associated with renal failure and has led to the development of novel therapeutic agents for its treatment

The outcome of statistical analysis for relevant experiment and figures is included in the Source Data File

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Vitamin C ng vai tr nh mt cht cho electron (electron donor), cung cp electron cho glutathione b oxy ha (GSSG), gip khi phc n tr li dng hot tnh (GSH)

GLP-1 must be used in conjunction with a healthy diet and exercise