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TNF- is one of the first few types of inflammatory cytokines to be released upon trauma and tissue injury, stimulating neutrophil and macrophage recruitment, signaling for downstream release of inflammatory cytokines, and triggering the differentiation of macrophages to the M1 pro-inflammatory phenotype (Figure 3A) [63]

Journal of Experimental Biology 2004

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Jones, 2002: Lagrangian data assimilation for point-vortex system