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Recovering the ability of the disc to repair the ECM, re-establishing the proteoglycan content, may have a significant therapeutic effect by increasing disc hydration and thereby improving its biomechanics (Vadal et al., 2015)

GH fine-tunes insulin and IGF-I signaling with no impact on IGF-II expression and has a minor impact on fetal development and growth

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Finally, a score of 5 corresponds to ulcers extending beyond 2 cm, accompanied by marked intestinal thickening and severe adhesion to surrounding organs

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