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MRD cells were also generated in vivo, by treating mouse xenografts of the 105K Tsc2 / RCC line in syngeneic C57BL/6J mice with rapamycin (3 mg/kg, intraperitoneally [IP] 3 times/wk for 1 month, MRD525), or the bi-steric inhibitor RMC-6272 (8 mg/kg, IP once/wk for 1 month, MRD639), followed by 2 months of treatment cessation (Figure 1A)

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As such, we aimed to investigate whether a larger glutathione pool could further aid in ensuring the cells survival

Salehi, B., Shetty, M

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They combine with pattern recognition receptors (PRRs) expressed by immune cells such as dendritic cells (DCs) and macrophages, initiating an immune response that allows the immune system to recognize and kill tumor cells