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It also improved the proliferative and secretory functions of fibroblasts and reversed morphological abnormalities of senescent cells (such as flattened cell shape, enlarged volume, and nuclear pyknosis)

Published Research on 5-Amino-1MQ Foundational DIO Mouse Study Neelakantan et al., Biochemical Pharmacology (2018) This paper introduced 5-Amino-1MQ as a selective and membrane-permeable small molecule inhibitor of NNMT and tested it in 3T3-L1 adipocytes and in male C57BL/6J mice maintained on a high-fat diet

[PMC free article: PMC5192543] [PubMed: 28090343] 19