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Statistical analysis The data has been analysed using students t test and One way ANOVA with p value cut off of 0.05 using Graph Pad Prism

However, expression in brain is considerably lower than in liver and kidney but not minimal

Mechanisms for the involvement of TDP-43 in neuronal degeneration have been hypothesized

ConjuChem was the originating Canadian pharmaceutical company

Biologic therapies such as Adalimumab (the first FDA-approved biologic for HS) [221,222,223], and Infliximab bind to and block the activity of TNF-, a major pro-inflammatory cytokine highly upregulated in HS lesions [224] (Fig

10 , e1001376 (2012)