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Bot M, et al

The second stage is Trem2-dependent and is marked by increased expression of genes involves in lipid metabolism and phagocytic pathway genes (e.g., Lpl, Cst , and Cd9 ), causing excessive inflammatory responses and neurodegeneration (Keren-Shaul et al., 2017

245,246 Hence, GLP-1 activates -cells and promotes somatostatin secretion, forming a multi-layered inhibitory mechanism that effectively reduces glucagon secretion

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