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Suppression of ODC1 activity appears to redirect ornithine metabolism toward urea production rather than putrescine, and because urea can be efficiently eliminated from astrocytes via the bloodstream and excreted in urine, no adverse effects were observed under the reported treatment regimen

Cabanillas ME, Zafereo ME , Williams MD, Ferrarotto R, Dadu R, Gross N, Gunn GB, Skinner H, Cote G, Grosu HB, Iyer P, Busaidy NL

Gonalves M, et al

Moreover, a randomized double-blind placebo-controlled clinical trial indicated that supplementation with Coenzyme Q10 (30 mg/day) and L-carnitine (500 mg/day) for 8 weeks had beneficial effects on migraine symptoms and serum levels of lactate (166)

The successful wet-laboratory experiment was thus the proof of concept of the model (Gajdanowicz et al., Reference Gajdanowicz, Michard, Sandmann, Rocha, Corra, Ramrez-Aguilar, Gomez-Porras, Gonzlez, Thibaud, van Dongen and Dreyer2011

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