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10.1016/j.neuro.2016.04.018 Neurotoxicology 128 SarkarA.SinghM

Ligand binding activates adenylyl cyclase, elevating intracellular cAMP and triggering PKA-mediated phosphorylation of downstream steroidogenic targets including CYP11A1, CYP17A1, and 3-HSD

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Yin, N., et al

Based on data present in literature, necroptosis is increased in the lungs of COPD patients and its inhibition attenuates CS-induced emphysema, airway inflammation, and remodeling making this process an attractive candidate for COPD patients