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It is produced by the body, recycled continuously and is found in fairly high concentrations in most human cells

The peptide's documented interaction with dopamine D2 receptors, including attenuation of amphetamine-induced hyperlocomotion and modification of haloperidol-induced catalepsy, suggests it could modulate the effects of dopamine agonists (pramipexole, ropinirole) or antagonists (antipsychotics) 4

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ROS active many signaling kinases (e.g., mitogen activated protein kinases), transcription factors (e.g., nuclear factor kB [NF-kB] and nuclear factor of activated T-cells [NFAT]), molecules that participate in calcium mobilization (e.g., ryanodine receptors [RyR2], SERCA 2A, calcium/calmodulin-dependent protein kinase II [CaMKII]), antioxidant proteins and others molecules involved in cardiac hypertrophy [151,152]