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10.1523/JNEUROSCI.2433-18.2018 62 MiyagiA.KawashiriT.ShimizuS.ShigematsuN.KobayashiD.ShimazoeT

133 Because tumor cells exchange intracellular glutamate for extracellular cystine through SLC7A11, intracellular glutamate is consumed, which causes cells to absorb more Gln and activate glutaminase to supplement intracellular glutamate, making cells with high expression of SLC7A11 become Gln-dependent