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Riluzole in cerebellar ataxia: a randomized, double-blind, placebo-controlled pilot trial

The Phase 1 clinical study of VIT-2763 demonstrated that serum iron levels and transferrin saturation declined transiently, and no obvious safety concerns were identified ( Targeting the hepcidin-ferroportin axis offers a novel therapeutic direction for patients with -thalassemia, particularly for those with NTDT, as it not only reduces iron overload but also improves anemia, decreases ineffective erythropoiesis, and alleviates splenomegaly

These studies indicate an oncogenic effect of L-2-HG and the association of L-2-HG with tumorigenesis under hypoxic conditions

[44] The incidence of side effects specific to a medication can be affected by the type of access (peripheral versus central), the rate of administration, or the quantity of drug administered

Schistosoma mansoni antigens modulate the activity of the innate immune response and prevent onset of type 1 diabetes

Most of the GCL holoenzyme can be reversibly dissociated by treatment with dithiothreitol [42], while oxidative stress may enhance holoenzyme formation as it increases GCL activity in the absence of any change in the expression of GCL subunits [45]