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Consistent with this, we observed that KEAP1NRF2 pathway inhibition curtailed the stemness features of chemoresistant MIBC cells, based on the findings that KEAP1 upregulation or NRF2 blockade significantly reduced tumor sphere formation, clonogenic growth and invasiveness, hallmarks of the stem cell-like, therapy-tolerant state

Carcinogenesis 27(10):20382046 Huang TY, Chang WC, Wang MY, Yang YR, Hsu YC (2012) Effect of sulforaphane on growth inhibition in human brain malignant glioma GBM 8401 cells by means of mitochondrial-and MEK/ERK-mediated apoptosis pathway