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Metabolites EGCG-2-cysteine and EGCG-2-cysteine were detected in urine following high-dose gavage of EGCG (233)

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Recent findings reveal that various molecules and pathways, including nuclear receptor coactivator 4, astrocyte-derived lactate, low-density lipoprotein receptor-related protein 1, and cGAS signaling, can influence cerebral IRI progression through unique lactylation mechanisms or by directly regulating overall lactylation levels [113,114,115,116]

Numerous therapies directed at specific targets have been suggested, some of which have yet to undergo clinical assessment

As used herein, therapeutically regulating skin condition includes ameliorating, e.g., diminishing, minimizing and/or effacing, discontinuities in skin, including signs of skin aging