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Originally identified by Loren Pickart in human plasma, GHK-Cu has been the subject of extensive cellular biology and biochemical research literature for over five decades, with research contexts examining tissue biology, cellular signaling pathways, copper-binding peptide chemistry, and extracellular matrix research

The effect of copper tripeptide and tretinoin on growth factor production in a serum-free fibroblast model

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This finding laid the groundwork for decades of research (noted in the table below) exploring copper-peptide signaling and its potential biomedical and cosmetic applications

PrP C undergoes basal to apical transcytosis in polarized epithelial MDCK cells

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