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Kopetz ES , Magnuson TH, Duncan MD, Bender JS, Lillemoe KD, Gordon TA, Cameron JL, Harmon JW

Leeches applied to the area concerned actively drain excess blood, and the anticoagulant effect of the leech saliva promotes the oozing of additional blood even after the leeches have been removed [173], helping to alleviate venous congestion in affected patients

doi: 10.1038/nbt.2989 38 Yesil-CeliktasOHassanSMiriAKMaharjanSAl-kharbooshRQuiones-HinojosaAet al

Additionally, the gut microbiota plays a critical role in learning and memory processes

Other mechanistic studies show that oral NAC is poorly absorbed with no renoprotective effects (53)