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Pandolfi A, Barreyro L, Steidl U (2013) Concise review: preleukemic stem cells: molecular biology and clinical implications of the precursors to leukemia stem cells

Food and Drug Administration (FDA)-approved treatments for ME/CFS ( Treating comorbidities ME/CFS displays an overlap with several autoimmune or immune-mediated diseases that also have chronic fatigue as a main symptom, such as Hashimotos thyroiditis (530), fibromyalgia (FM) (532, 554557), Mast Cell Activation Disorder (532), sleep apnoea (532), IBS (532), secondary depression or anxiety (532), Ehlers-Danlos syndrome (532), and PoTS (532, 558563)

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On the other hand, AR also utilizes NADPH to convert glucose to sorbitol, which depletes intracellular NADPH, making GSSG irreducible and promoting oxidative stress 18