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Hyaluronate-gold nanoparticle/tocilizumab complex for the treatment of rheumatoid arthritis

Physiological Role : Epinephrine is produced primarily by the adrenal gland, and plays an essential role in producing various physiological respones under fight of flight conditions in response to stimulation of the adrenal gland by preganglionic sympathetic nerves

Quercetin-induced pyroptosis in colon cancer through NEK7-mediated NLRP3 inflammasome-GSDMD signaling pathway activation

Cell 80 , 796809.e9 (2020)

presented a heterozygous CHAC1 deletion mouse model that was protected from kidney disease progression across three different disease models, without any known phenotypic changes under control conditions ( Despite its injury-promoting effects in some organs, CHAC1 contributes to tissue repair in certain contexts

It becomes the tipping point that overwhelms a nervous system already compromised by earlier events