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Supplementary material The Supplementary Material for this article can be found online at: Abbreviations TMAU, trimethylaminuria

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Mitochondrial abnormalities is ASD patients are consistent with PPA toxicity ETC function testing in muscle demonstrated a partial deficit in complexes I/III and I/III RS activity

Caffeine, however, does increase heart rate and insomnia and can have significant negative health effects, including death, if taken in too high of a dose

Acknowledgements We would like to thank Editage (www.editage.cn/) for providing expert linguistic assistance

The team also examined microbial communities in human feces, and looked at L-carnitine and TMAO concentrations in the blood of a large group of people undergoing elective cardiac evaluation