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(10) Kidney problems: Too much vitamin D can lead to abnormally high calcium levels, which result in water loss via excessive urination and calcification of the kidneys

Wischhusen, J., Melero, I

First, clarifying the isoform-specific roles of AMPK, particularly AMPK1 versus AMPK2 in distinct cardiac cell types, is essential for understanding the context-dependent nature of metformins effects

Additionally, most studies have been conducted over short durations, which might not allow time for adverse effects to manifest