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88 In recent years, studies have revealed that UA activates the TLR4-NLRP3 inflammatory complex, which is a multi-protein complex that plays a pivotal role in initiating the innate immune response to various danger signals, including MSU crystals

In horses, lysine is the first limiting amino acid meaning it is most likely to be low in the diet and protein synthesis rates will not be optimal until there is enough lysine

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It plays an important role in the synthesis and oxidation of fatty acids, pyruvate oxidation in the citric acid cycle, and other biological processes

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Therefore, in this study, an oxidative stress-induced senescence model in HaCaT cells was established using H 2 O 2