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Post-translational modification (PTM) of proteins involves the addition of moieties to target residues

Moreover, CA, is transdiagnostically associated to psychiatry morbidity, and seems to play a role in the DNAm dysregulation of many of these pathways

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APOE-4 exhibits strong sex-dependent effects, with womenparticularly in mid-to-late older adulthoodshowing greater vulnerability to ADrelated neurodegeneration than men, including increased tau accumulation, more pronounced hippocampal and temporal cortical atrophy, and greater cognitive and neuropsychiatric burden (118, 121, 122)

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It is administered via injection to ensure rapid absorption and effectiveness in addressing Vitamin B12 deficiency