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More recently, 16HBE14o-line has been utilized as a platform for CRISPR/Cas9-mediated gene editing to introduce specific rare CF-causing mutations (e.g., W1282X, N1303K)

T.ChacunH.PradierL.et al (2014)

Despite no significant difference in the total bacterial load, specific bacterial taxa were differentially abundant, with the presence of Streptococcus in the ESCC TME correlating with an activated tumor immune microenvironment and improved therapeutic efficacy of neoadjuvant chemotherapy combined with immunotherapy