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Dependency on host vitamin B12 has shaped Mycobacterium tuberculosis Complex evolution

Indeed, when cultured in absence of serine/glycine, control cells exhibited impaired proliferation, while NKX2-1 overexpressing cells continued to proliferate, showing that increased serine/glycine synthesis enables cancer cells to become independent of exogenous serine for proliferation

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Among these, drug combinations targeting distinct epigenetic mechanisms, such as DNA methylation and histone modifications, are the primary focus of research because they can more thoroughly reactivate TSGs or inhibit oncogenic pathways through synergistic effects [18]