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[DOI] [PMC free article] [PubMed] [Google Scholar] 43.Li N., Lewis P., Samuelson D., Liboni K., Neu J

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Higher-risk profile Patients at higher risk from this combination include: those taking amlodipine 10 mg/day (the maximum approved dose), adults over 65 (CYP3A4 activity naturally declines with age [2]), anyone with a baseline systolic blood pressure at or below 130 mmHg on current therapy, patients taking other CYP3A4 inhibitors (azithromycin, fluconazole, grapefruit juice), and anyone with concurrent heart failure or severe aortic stenosis where cardiac output depends on adequate preload