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Following a one-week acclimatization phase, experimental procedures were conducted in accordance with international animal care and ethical guidelines, approved by Cairo Universitys local committee on animal care and use (CU/I/F/28/19), and reported in accordance with ARRIVE guidelines

Mitochondria (Organelle Source of ROS) The mitochondria are the primary intracellular generator of ROS

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Additionally, NDGA enhances H 2 O 2 sensitivity and increases Mtz sensitivity in H

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Am J Hum Genet 78(6):988998 Almaguer-Gotay D, Almaguer-Mederos LE, Aguilera-Rodrguez R, Rodrguez-Labrada R, Cuello-Almarales D, Estupin-Domnguez A et al (2017) Spinocerebellar ataxia type 2 is associated with the extracellular loss of superoxide dismutase but not catalase activity