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Reduced-intensity conditioning regimens have also been studied in related and unrelated HSCT, and while a suitable option for patients with a matched sibling, patients with unrelated donor should be made aware of the not-so-favorable short and long-term outcomes ( As new transplant modalities emerge with less transplant related mortality, better immunomodulators to prevent GVHD are being developed and graft rejection has become less frequent and accepted indications for HSCT have become less restrictive (Table 2)

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Acknowledgements This work was supported by the Academic Research Fund (R-279-000-476-112) of the National University of Singapore, Biomedical Research Council of A*STAR (Agency for Science, Technology and Research), Singapore, and grants from the Next-Generation BioGreen 21 Program (SSAC, No

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