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Amino acids are the fundamental components of proteins and are necessary in many internal functions of the body

One of the intermediates in the formation of kyn from tryptophan metabolism, N-formyl-kynurenine (NFK), differs from other tryptophan metabolites in its photophysical properties, in that it acts as a photosensitiser to produce singlet oxygen and superoxide (103, 104)

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Direct tissue temperature measurements suggested that therapeutic freezing may not have extended across the full diameter of the sciatic nerve, highlighting a key technical limitation that may explain the lack of clinical benefit